A Review Of neuropathic pain



Neuropathy is a general term denoting disruptions in the typical functioning of the peripheral nerves. The causes of neuropathy are diverse therefore is the treatment. Many a times, the neuropathy is almost irreparable and the treatment is primarily focused on preventing more development of the nerve damage and other supportive measures to avoid any problems due to neuropathy.

Neuropathies due to nutritional shortages are generally treated with the replenishment of the deficient nutrient. Neuropathies due to deficiency of vitamins like cobalamin, thiamine, pyridoxine, niacin are dealt with by providing the vitamin supplementation orally or by intramuscular injection of the vitamin if deficiency is because of faulty absorption of vitamins from the diet. Treatment might or might not totally reverse the neuropathy and alleviate the signs and in numerous cases there is some permanent damage to nerves and relentless signs in spite of therapy. Just recently neuropathy due to copper deficiency has likewise been found. It too is treated with oral copper salts or intravenous injection of copper salts. Again the action varies and may take lots of months.

Entrapment neuropathies like carpal tunnel syndrome, radial neuropathy, meralgia paraesthetica, etc are dealt with based on particular cause and the nerve included. Carpal tunnel syndrome treatment varies from medical techniques like NSAID (like Ibuprofen), regional injection of steroids in wrist, and avoiding irritating elements like typing in wrong positions, usage of hand tools etc. If symptoms not eased by this method, then surgery is likewise a choice and is frequently alleviative if no permanent damage to nerve has actually currently occurred. Again, each neuropathy is special and treatment varies.

The treatment of neuropathies secondary to other diseases is the treatment of the main disease causing the neuropathy. If neuropathy is because of Myxedema, brought on by absence of thyroid hormone, then treatment is replacing the thyroid hormonal agent. Treatment of Diabetic Neuropathy is mainly encouraging. In diabetic neuropathies, some types like Mononeuropathies are reversible but a lot of are irreversible. Rigorous control of blood glucose levels to slow the further development is of paramount value. Other treatment is based on the signs, like pain is managed with NSAID and numerous other drugs. The neuropathy associated with Rheumatoid Arthritis frequently responds to the treatment of Rheumatoid arthritis (with immunomodulators).

Treatment of neuropathy due to food allergic reaction is avoiding the irritant food item causing neuropathy. Neuropathy might also be because of harmful result of specific drugs like Chloroquine, Phenytoin, anti-Cancer drugs and numerous others. Treatment in this case is mainly discontinuation of the drug or dosage reduction. There might be some specific treatment in particular cases, like neuropathy due to isoniazid can typically be avoided by providing pyridoxine in addition to it.


Many a times, the neuropathy is nearly irreversible and the treatment is generally focused on preventing more progression of the nerve damage and other encouraging steps to avoid any problems due to neuropathy.

Entrapment neuropathies like carpal tunnel syndrome, radial neuropathy, meralgia paraesthetica, etc are dealt with based on specific cause and the nerve included. The treatment of neuropathies secondary to other diseases is the treatment of the main disease triggering the neuropathy. Treatment of neuropathy due to food allergy is preventing the allergen food product causing neuropathy.

Whatever the initial cause, your nerves reacted with the only survival tool they had: they contracted, they decreased their length and volume to protect themselves, and the spaces between the nerves(synapse) were extended. A regular sized nerve signal could no longer jump this space. Thus nerve impulses, both those going up to the brain and those coming down from the brain were impaired.

Built-in microprocessors steps numerous physiological functions of your nerves and automatically changes itself to your particular therapeutic needs, starting with the very first healing signal.

When the unit is first switched on, it determines the electrical analog resistance and digital impedance and sets its output parameters for your physical mass. If it is treating a 125 lb female or a 350 pound man, it understands. It understands that if you utilize it directly on your lower back.

Specialized stimulator then sends out a "test" signal that represents the most typical waveform for healthy peripheral nerves. This signal goes from one foot, up the leg, to the nerve roots in your lower back, down the other leg, to the other foot. It then awaits an echo-like response from this initial signal.
It then examines this 'return" signal to figure out any aberrations.

Just as a cardiologist can take one take a look at the shape of the signal showed on an EKG display, and diagnose what is incorrect with the heart, we have actually been able to identify that the peripheral nerves have an extremely specific shape to its waveform. Therefore we can diagnose the nature of the issue by examining that waveform. This function is constructed into the stimulator and processed by its internal microprocessor.

Abnormalities in the shape of the waveform on the way up shows concerns with numbness; the shape of the top of the waveform suggests the ability of the nerve to deliver the signal enough time for the brain to get it all; abnormalities in the down slope of the waveform shows pain, and the shape of the refractory period as the nerve cell repolarize's itself suggests the capability of the nerve pathway to prepare for the next signal.

The device needs to then develop, and send, a compensating waveform, to 'smooth website out' these abnormalities, really comparable to the way noise canceling earphones work.

This procedure goes on 7.83 times every 2nd, sending a signal, analyzing the returning signal, producing a compensating signal, and sending this new signal. It is constantly evaluating your action, and adjusting itself, to gently coax your nerve's ability to send out and get correct signals.

These impulses are sent out 7.83 times per 2nd because that is how long it takes for the nerve cell to re-polarize (or reset) itself between its transmission of nerve signals. Minerals like salt, potassium, and calcium need to pass back and forth through the cell wall of the nerves. This is why a common TENS merely blocks the nerve signals.

The signals, (as they cross the synaptic junctions in the nerve roots of the lower back to get from one leg to the other), develop a little electromagnetic field that is sensed by the nerves in your main worried system (spinal column) and a signal is submitted to the brain to let it know exactly what is occurring in the lumbar area. The brain then launches endorphins, internal discomfort relievers that travel through the blood stream to all parts of the body.


Whatever the initial cause, your nerves reacted with the only survival tool they had: they contracted, they lowered their length and volume to preserve themselves, and the gaps between the nerves(synapse) were stretched. A typical sized nerve signal might no longer leap this space. Specialized stimulator then sends out a "test" signal that represents the most common waveform for healthy peripheral nerves. These impulses are sent 7.83 times per second because that is how long it takes for the nerve cell to re-polarize (or reset) itself in between its transmission of nerve signals. The signals, (as they cross the synaptic junctions in the nerve roots of the lower back to get from one leg to the other), produce a little electro-magnetic field that is picked up by the nerves in your central nervous system (spine) and a signal is submitted to the brain to let it know exactly what is happening in the lumbar area.

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15

Comments on “A Review Of neuropathic pain”

Leave a Reply

Gravatar